The Plasmodium falciparum parasite, which is responsible for malaria, has developed resistance to several first-line antimalarial drugs. To address this issue, researchers have been developing novel hybrid molecules that can inhibit parasitic growth. A total of 38 chalcone oxime ethers, consisting of four different types, were used for in vitro blood-stage antiplasmodial evaluation against P. falciparum (3D7). The four classes of oxime ethers showed promising to moderate antiplasmodial activity. At least one molecule from each class was potent, with IC