Incident tuberculosis in people with HIV across Europe from 2012-2022: incidence rates, risk factors, and regional differences in a multicentre cohort study.

• Tác giả: Alain Volny Anne, Elzbieta Bakowska, Marie Ballief, Elena Borodulina, Antonella Castagna, Nikoloz Chkhartishvili, Antonella d'Arminio Monforte, Harmony Garges, Dennis Israelski, Nadine Jaschinski, Ole Kirk, Michael Knappik, Christian Kraef, Amanda Mocroft, Christina Mussini, Bastian Neesgaard, Johannes Nemeth, Marie-Christine Payen, Daria Podlekareva, Ashley Roen, Elmar Wallner, Ferdinand Wit
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.942 Unidentified flying objects (UFOs)
• Thông tin xuất bản: England : The European respiratory journal , 2025
• Bộ sưu tập: NCBI
• ID: 235032

Tóm tắt

 BACKGROUND: Tuberculosis remains the leading cause of death among people with HIV. The aim of this study was to describe the incidence of tuberculosis (TB), explore risk factors and to calculate their population attributable fractions (PAF) in people with HIV across Europe, stratified by region. METHOD: Longitudinal study of people with HIV aged>
 18 years with follow-up from either 1/1/2012, or cohort enrolment, until date of TB diagnosis, last visit, death, or 31/12/2022. Factors associated with TB, in particular antiretroviral therapy status and smoking, were analysed using multivariable Poisson regression. RESULTS: A total of 38 837 participants with HIV with a median follow-up of 7.7 (4.3-10.4) years. Overall, 306 TB cases were diagnosed during 275 811 person-years of follow-up (PYFU
  incidence rate (IR) 1.03/1000 PYFU, 95% CI 0.91-1.11). 3.3% ( CONCLUSIONS: TB incidence has been decreasing among people with HIV, but remains more frequent in Eastern Europe. Improvement of antiretroviral therapy-coverage and adherence and a focus on non-communicable disease risk factors such as smoking could reduce the incidence of TB.