BACKGROUND: Anesthesiology, as the core field of the treatment of critically ill patients, carries great work risks and pressure. Due to the uniqueness of their working environment and nature, medical staff have become a high incidence group of sleep-related worry and sleep disorders. OBJECTIVE: To investigate the sleep status of anesthesia nurses and analyze related influencing factors, so as to provide a reference for formulating targeted intervention measures. METHODS: This study was a cross-sectional study design. From August to October 2024, convenience sampling was used to investigate 330 nurses in the Department of anesthesia in Sichuan Province of China with the general information questionnaire, Sleep-related Worry scale, Self-regulatory Fatigue Scale, Perceived Stress Scale, Athens Insomnia Scale and Perceived Social Support Scale. Single factor analysis, Pearson correlation analysis and multiple hierarchical regression analysis were used to explore the influencing factors of sleep-related worry of nurses in the department of anesthesiology. RESULTS: The total score of sleep-related worry was (32.53 ± 12.00), the score of self-regulatory fatigue was (47.01 ± 9.25), the score of stress perception was (28.84 ± 7.96), and the score of insomnia was (17.18 ± 6.24). The score of perceived social support was (61.56 ± 14.93). Sleep-related worry was positively correlated with self-regulatory fatigue (r = 0.459, P <
0.001), perceived stress (r = 0.489, P <
0.001), Athens insomnia (r = 0.671, P <
0.001), and negatively correlated with perceived social support (r=-0.362, P = 0.002). The results of multivariate analysis showed that health status, self-regulatory fatigue, perceived stress, insomnia and social support were the influencing factors of sleep-related worry of nurses in the department of Anesthesiology, which could explain 51.1% of the total variation. CONCLUSION: Anesthesiology nurses have serious sleep-related worry, which need to be further improved. Clinical nursing managers should pay attention to the special needs of nurses in the department of anesthesiology, and reduce the sleep-related worry of anesthesiology nurses by improving their insomnia symptoms, reducing their stress and self-regulatory fatigue, and improving the level of social support.