Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies

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Tác giả: Aditi Singh, Mohammad W. Khan

Ngôn ngữ: eng

ISBN-13: 978-1838806965

Ký hiệu phân loại:

Thông tin xuất bản: IntechOpen, 2019

Mô tả vật lý: 1 electronic resource (134 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 235738

RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.
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