Supply chain risk has become a major area of concern for companies in the agribusiness sector, as well as for their customers, financiers, and external stakeholders. The threats that environmental and social (E and S) risks pose to brand values and product quality are making those risks more material, often reaching thresholds of major importance to the core business of agriculture and food companies. This good practice handbook is intended for those agro-commodity companies that want to better manage supply chain E and S risks. Agro-commodity supply chains often stretch over multiple supplier companies and multiple countries. Through its eight performance standards on E and S sustainability, the International Finance Corporation (IFC) requires its clients to identify, avoid, mitigate, and manage E and S risks and impacts as a way of conducting sustainable business. IFC recognizes that there is a broader range of significant E and S risks in agro commodity supply chains beyond these four core areas, and the approach set out in this handbook can be applied beyond these areas. The handbook focuses on five major agro-commodity supply chains- palm oil, soy, sugarcane, cocoa, and coffee however, many of the tools, resources, and case studies can be used as guidance for other agro-commodities.