OBJECTIVE: Autoimmune Addison´s disease (AAD) is associated with reduced health-related quality of life and possibly reduced employability. The aim of this study was to assess differences in income and work loss between patients with AAD and matched comparators. DESIGN: Nationwide, cross-sectional register-based study. METHODS: By linking the Swedish Addison Register and national health registers, we identified working age (18-64 years) individuals with AAD and general population comparators (matched 1:5 by sex, age and county of residence). We assessed differences in taxable earnings and disposable income through quantile regression and differences in work loss through linear regression during 2019. RESULTS: We identified 1,140 cases with AAD and 5,700 comparators (mean age 46.1 years, 48.4% men). Type 1 diabetes was prevalent in 15.7% and 1.1%, respectively. Work loss was higher in AAD
adjusted mean difference 14.4 days
95% CI, 8.6-20. The adjusted median differences in taxable earnings and disposable income were non-significant overall at -617 (95% CI
-2,317 to 1,083) and -405 (95% CI
-1,417 to 607) €. However, significantly lower taxable earnings and disposable income were found among patients with short education: -5,303 (95% CI
-9,603 to -992) and -3,754 (95% CI
-6,486 to -1,022) €, or concomitant type 1 diabetes: -5,808 (95% CI
-9,937 to -1,690) and -3,349 (95% CI
-6,203 to -506) €. CONCLUSION: Patients with AAD had more work loss, yet overall similar taxable earnings and disposable incomes versus comparators. Patients with AAD with shorter education or type 1 diabetes were most socioeconomically vulnerable.