Association between serum uric acid and the risk of breast cancer: A meta-analysis of observational studies.

• Tác giả: Longbo He, Qingfeng Luo, Lieliang Wang, Liping Yang, Ziyun Yu, Jin Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 149.73 Skepticism
• Thông tin xuất bản: United States : The International journal of biological markers , 2025
• Bộ sưu tập: NCBI
• ID: 236958

Tóm tắt

 BACKGROUND: The relationship between serum uric acid and breast cancer remains uncertain. This meta-analysis aimed to elucidate the dose-response association between elevated serum uric acid levels and breast cancer risk. METHODS: We systematically searched PubMed, Embase, and Web of Science for observational studies evaluating serum uric acid and breast cancer risk in adult women. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. RESULTS: Ten studies were included. High serum uric acid was associated with an increased breast cancer risk (RR: 1.34
  95% CI: 1.03-1.73
  CONCLUSION: Serum uric acid may be nonlinearly associated with the risk of breast cancer (U-shaped). The risk of breast cancer increases with serum uric acid above 4.5 mg/dL, and a higher association between serum uric acid and the increased risk of breast cancer could be observed in studies with cutoff of serum uric acid  >
  5.4 mg/dL.