To compare outcomes, complications, and costs between endoscopic and open surgical approaches in the management of craniosynostosis using a large national database. Retrospective cohort study. National Inpatient Sample database, including inpatient hospital discharge data from 2018 to 2021 across 48 states and Washington, D.C. The present study included 1099 patients admitted with a primary diagnosis of craniosynostosis. Among them, 183 (16.6%) underwent endoscopic surgery and 916 (83.3%) underwent open surgery. Surgical management of craniosynostosis, classified as either an endoscopic or open approach. Length of hospital stay, total procedure costs, and rates of inpatient complications, including surgical and medical complications. Endoscopic surgery was associated with a significantly shorter length of stay (mean 1.6 days vs 3.7 days,