Effect of a high-fat diet and iron overload on erythropoiesis in mice.

• Tác giả: Molly Jacob, Jithu James Varghese, Joe Varghese
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.737 Measures to prevent, protect against, limit effects of pollution
• Thông tin xuất bản: Netherlands : Biochemistry and biophysics reports , 2025
• Bộ sưu tập: NCBI
• ID: 237136

Tóm tắt

 BACKGROUND: Insulin and iron availability stimulate and regulate erythropoiesis, respectively. The effects of hyperinsulinemia and/or iron overload on erythroid differentiation are unclear. METHODOLOGY: Male C57Bl/6J wild-type (WT) mice were fed a high-fat diet (HFD) (to produce hyperinsulinemia) or a control diet (CD) for varying periods (4-24 weeks). Hepcidin knock-out ( RESULTS: HFD-feeding of WT mice did not significantly affect erythroid precursors in the BM or hematological parameters. However, these mice had a significantly higher reticulocyte population in the BM than those fed CD (at all time points studied). Values of hematological parameters were higher in CONCLUSIONS: HFD-feeding in WT mice resulted in increases in the proportion of reticulocytes in the bone marrow
  maturation of the early erythroid precursors was not significantly affected. In