BACKGROUND AND AIMS: Conduct a pilot randomized double-blind placebo-controlled crossover trial for adults with subthreshold insomnia symptoms to examine the effectiveness of a cannabinoids supplement on sleep quality and health outcomes. METHODS: Adults with subthreshold insomnia symptoms ( RESULTS: When compared to PC, the CS Condition had significantly improved sleep quality/efficiency, insomnia symptoms, and health-related quality of life, CONCLUSION: This cannabinoid-based formulation was a well-tolerated oral supplement that may improve adults' sleep quality/efficiency and health-related quality of life. Larger controlled trials are encouraged to examine the longer-term effects of this supplement in a variety of populations and environments.