BACKGROUND AND AIMS: The biopsychosocial (BPS) model considers that health and behavioral outcomes result from the interaction of biological, psychological, and social factors. Regular exercise is an essential component of modern-day healthy living. All three factors in the BPS model are related to long-term exercise. Therefore, this cross-sectional study aimed to compare adults exercising regularly for at least 3 years with their non-exercising counterparts on perceived health and stress (antagonistic, biopsychological), life satisfaction (psychological), and perceived income (psychosocial) while controlling for age, gender, and education level. METHODS: Participants were 461 Hungarian volunteers (74.83% female) aged 18-73 years. There were 274 regular exercisers and 187 non-exercisers. They completed the study on the Qualtrics research platform. RESULTS: A statistically significant ( CONCLUSION: These findings support the idea that long-term exercise behavior can be studied via the BPS model and the role of stress in life satisfaction. The results have practical implications for promoting a healthy and satisfactory life targeting multi-level development through exercise based on the BPS model.