Micro-environmental changes indicate potential for subclinical intestinal tissue damage in early-age-onset colorectal cancer patients.

• Tác giả: Linda Clipson, Dustin A Deming, Philip B Emmerich, Katherine A Johnson, Sean G Kraus, Kristina A Matkowskyj, Cheri A Pasch, Wei Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 552.3 Plutonic rocks
• Thông tin xuất bản: England : Gastroenterology report , 2025
• Bộ sưu tập: NCBI
• ID: 237424

Tóm tắt

 BACKGROUND: While improved screening rates have contributed to an overall decrease in the incidence of colorectal cancer (CRC), the incidence of early-age-onset CRC (EAO CRC
  age <
 50 years) has increased. Here, we characterize the genetic alterations and tumor microenvironment (TME) for EAO and later-age-onset (LAO) CRCs to identify relevant biological differences that might point to etiologic factors. METHODS: A cohort of EAO ( CONCLUSIONS: Overall, established EAO cancers are similar to LAO cancers in mutational profile and key TME features. High VCAN and αSMA expression in adjacent normal colon indicates a presence of factors that are associated with increased intestinal subclinical inflammation. Future mechanistic studies will be conducted to better understand the importance of these findings and related processes should be prioritized as potential etiologic factors for EAO tumorigenesis.