BACKGROUND: People with type 2 diabetes mellitus who have clinical inertia often struggle to control their blood sugar levels and do not receive timely treatment intensification. Strict glycemic control has advantages, but many patients with diabetes are unable to reach their target blood sugar levels. The study's main objective was to determine the prevalence of clinical inertia in patients with type 2 diabetes at Debre Tabor Comprehensive Specialized Hospital(DTCSH) in Ethiopia. METHODS: An institutional based, cross-sectional research design was used at Debre Tabor Comprehensive Specialized Hospital from November 20/2023 to January 30/2024. A structured questionnaire modified from various medical records and literatures were used to gather data. A logistic regression model was also employed after the Hosmer-Lemeshow goodness-of-fit test was checked to find contributing variables to clinical inertia. A threshold of p <
0.05 was considered statistically significant. RESULT: In total, 287 samples were included in the research. The occurrences of clinical inertia 31.4% (95%CI: 25.9 - 36.8) were obtained from 90 patients. Aged patients (AOR = 1.103
95% CI, 1.034 - 1.176
P = 0.003), medication fee (AOR = 4.955
95% CI, 1.284 - 14.127
P = 0.020), medication nonadherence (AOR = 4.345
95% CI, 2.457 - 15.537
P = 0.001), increase number of medication (AOR = 4.205
95% CI, 2.657- 6.655
P ≤ 0.001), poor glycemic control (AOR = 2.253
95% CI, 1.673 - 3.033
P ≤ 0.001) were more likely to have clinical inertia. CONCLUSION: One-third of patients experienced clinical inertia. Age, glycemic control, medication non-adherence, treatment fee, and number of medications were found to be strongly correlated with clinical inertia. More precise knowledge of the clinical inertia and the associated therapies is necessary to tackle this issue more effectively.