Family study of bipolar disorder with comorbid anxiety disorder points to

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Tác giả: Kumiko Fujii, Takashi Hayama, Yuki Kageyama, Muneko Kataoka, Tadafumi Kato, Hiroaki Maki, Koji Matsuo, Masaki Nishioka, Naomi Sakai

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Australia : PCN reports : psychiatry and clinical neurosciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 237471

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AIM: The aim of this study was to provide new insights into the genetics of bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders. METHODS: Structured interviews were conducted with BD patients and their parents. Cases were classified into those with comorbid anxiety spectrum (AS) and those without. The family history of patients with BD with comorbid AS was assessed. Focusing on parent-of-origin effects and genomic imprinting from the results, imprinted genes and tested single nucleotide polymorphisms (SNPs) in the identified genes were investigated for an association with BD by transmission disequilibrium test (TDT) using published whole-exome sequencing data. RESULTS: The incidence of comorbid AS among all the patients with BD analyzed in this study was 39.6%. Patients with BD whose fathers had AS or mood disorders exhibited a significantly higher rate of AS. Among the known imprinted genes, two were associated with BD:

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