To date, there is no clear evidence supporting the use of caffeine therapy in bronchiolitis-related apnea in pediatric intensive care units. Generalizing the approach for all bronchiolitis cases could be behind this limitation of the evidence. Here, we report a successful use of caffeine citrate for a neonate with bronchiolitis-related apnea. Understanding the limitations of case reports, we think being a neonate diagnosed with bronchiolitis-related apnea without respiratory distress, on top of a prematurity background, might be the key characteristic for this successful use.