Residue depletion profile and withdrawal interval estimation of ivermectin in eggs following topical administration of injectable ivermectin to domestic chickens (

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Tác giả: Maaike O Clapham, Jennifer L Davis, Melissa A Mercer, Lisa A Tell, Scott E Wetzlich

Ngôn ngữ: eng

Ký hiệu phân loại: 363.7298 Environmental problems

Thông tin xuất bản: Switzerland : Frontiers in veterinary science , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 238342

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INTRODUCTION: Topical ivermectin is commonly prescribed extra-label for the control of mite infestations in backyard chicken flocks in the US. METHODS: Domestic laying hens ( RESULTS: The average period between eggs laid was 1.52 days. Ivermectin preferentially distributed to the egg yolk with an observed DISCUSSION: This study improves the understanding of the residue depletion kinetics of ivermectin in eggs after topical administration to older hens with inconsistent egg production. Ivermectin is systemically absorbed following topical administration of the injectable formulation in domestic egg laying chickens, resulting in prolonged egg residues. Ivermectin is preferentially distributed to the egg yolk over the egg white following topical administration of the injectable formulation in egg laying chickens. Since plasma kinetics were not evaluated, the impact of systemic exposure on egg residue kinetics following topical administration remains unknown. The results provide insight into how the estimated ivermectin egg WDIs using regulatory methods differ based on the maximum residue limit/tolerance applied and portion of the terminal elimination phase sampled.

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