BACKGROUND: Myocardial calcification is an unusual complication of septic cardiomyopathy. Dystrophic calcification may occur after damage to myocardial tissue, but its occurrence is rare. CASE SUMMARY: A 42-year-old pregnant woman with no past medical history was admitted in intensive care for respiratory distress caused by bacterial superinfection of influenza. Subepicardial calcification of the left ventricle appeared on a computed tomography at Day 8. Calcification worsened quickly, but we observed a paradoxical improvement in left ventricle function, as assessed by left ventricular ejection fraction and global longitudinal strain using echocardiography with speckle tracking. DISCUSSION: The pathophysiology of myocardial calcification is not fully understood, but prolonged haemodynamic failure, profound acidosis, high vasopressor doses, and acute respiratory distress syndrome were previously associated with septic-related myocardial calcification.