We present a case of a patient with pyoderma gangrenosum, a rare complication associated with surgical procedures. Breast reduction is the second most common etiology within this category. This case emphasizes the importance of early diagnosis to start therapy on time to stop the inflammatory process and prevent its progression, achieving adequate re-epithelialization, as well as emphasizes the use of an immunomodulator with steroid treatment to offer better results that impact the quality of life positively.