INTRODUCTION: Biostatistics is an increasing focus in both the United States Medical Licensing exams (USMLE) and medical school curricula. Nonetheless, literature has documented that it is poorly understood among both practicing physicians and physician trainees. Our purpose is to narrow this knowledge gap by offering readers a "how-to" guide that both supplements essential biostatistics knowledge and assists in constructing research projects. METHODS: In Part II of our tandem manuscripts, we expand our Part I biostatistics analysis of research articles in the RESULTS: Understanding biostatistics requires interpreting the type of study, type of data collected, statistical tests available for all types of data, and results of the statistical tests. CONCLUSION: Gaining proficiency in biostatistics will improve the precision of evidence-based medical outcomes, helping close the current knowledge gap among practicing physicians and trainees.