First synthesis of (difluoroiodomethyl)thiophenes through double iodation of 2-(difluoromethylene)but-3-yn-1-yl benzyl sulfides.

• Tác giả: Takeshi Hanamoto, Daiki Komatsu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 158.723 Job burnout
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 239007

Tóm tắt

The Sonogashira cross-coupling of 2-bromo-3,3-difluoroallyl benzyl sulfide with various terminal acetylenes afforded the corresponding 2-(difluoromethylene)but-3-yn-1-yl benzyl sulfides in acceptable to good yields. Subsequent double iodation of the enyne sulfides in a mixed solvent (CHCl