Understanding the Link Between Functional Profiles and Intelligence Through Dimensionality Reduction and Graph Analysis.

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Tác giả: Francesco Alberti, Daniel S Margulies, Arianna Menardi, Antonino Vallesi

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Human brain mapping , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 239114

There is a growing interest in neuroscience for how individual-specific structural and functional features of the cortex relate to cognitive traits. This work builds on previous research which, by using classical high-dimensional approaches, has proven that the interindividual variability of functional connectivity (FC) profiles reflects differences in fluid intelligence. To provide an additional perspective into this relationship, the present study uses a recent framework for investigating cortical organization: functional gradients. This approach places local connectivity profiles within a common low-dimensional space whose axes are functionally interpretable dimensions. Specifically, this study uses a data-driven approach to model the association between FC variability and interindividual differences in intelligence. For one of these loci, in the right ventral-lateral prefrontal cortex (vlPFC), we describe an association between fluid intelligence and the relative functional distance of this area from sensory and high-cognition systems. Furthermore, the topological properties of this region indicate that, with decreasing functional affinity with high-cognition systems, vlPFC functional connections are more evenly distributed across all networks. Participating in multiple functional networks may reflect a better ability to coordinate sensory and high-order cognitive systems.
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