Ruthenium (Ru) -based catalysts have been considered a promising candidate for efficient sustainable hydrogen and chlor-alkali co-production. Theoretical calculations have disclosed that the hollow sites on the Ru surface have strong adsorption energies of H and Cl species, which inevitably leads to poor activity for cathodic hydrogen evolution reaction (HER) and anodic chlorine evolution reaction (CER), respectively. Furthermore, it have confirmed that anchoring Lewis acid oxide nanoparticles such as MgO on the Ru surface can induce the formation of the onion-like charge distribution of Ru atoms around MgO nanoparticles, thereby exposing the Ru-bridge sites at the interface as excellent H and Cl adsorption sites to accelerate both HER and CER. Under the guidance of theoretical calculations, a novel dispersed MgO nanoparticles on Ru (MgO