Routine screening mammography can decrease the mortality from breast cancer by early detection. Dense breast tissue limits the detection of cancer with mammography alone, and the use of supplemental imaging to improve early detection is necessary in these patients. For women with dense breasts who would benefit from supplemental screening, modalities, such as MRI, whole breast ultrasound, contrast-enhanced mammography, and molecular breast imaging, are available to aid in the detection of mammographically occult cancers.