Cardiometabolic diseases (CMDs) are a significant public health burden in Cameroon, driven by lifestyle factors such as poor diet, physical inactivity, and tobacco use. The current response to this growing epidemic is inadequate, with limited screening and insufficient implementation of effective behaviour change interventions. To address this, a multi-pronged approach is crucial. This approach should encompass enhanced screening efforts through the integration of CMD risk factor assessments into routine healthcare visits and the implementation of community-based screening programs. Furthermore, promoting behaviour change interventions is vital, including health education, peer support groups, and training healthcare providers in motivational interviewing techniques. Strengthening healthcare systems is essential, requiring increased government investment in primary healthcare, improving access to quality care, and establishing a robust surveillance system to monitor the burden of CMDs. By implementing these strategies, Cameroon may effectively combat the rising tide of CMDs and improve the overall health and well-being of its population.