Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster.

• Tác giả: Ying Chen, Hao-Hao Deng, Zi-Qing Deng, Mei Dong, Yun Gao, Qian-Chun Gong, Zi-Shuo Guo, Pan-Pan Hou, Li-Na Ji, Ren-Di Jiang, Ting-Ting Jiang, Ya-Na Lai, Bei Li, Jian-Min Li, Qian Li, Hao-Feng Lin, Xin-Hua Lin, Mei-Qin Liu, Yun-Zhe Luo, Chen Qiu, Xu-Rui Shen, Ai-Min Shi, Zheng-Li Shi, Qi Wang, Xi Wang, Zi-Yi Wang, Wen-Tao Zeng, Ya Zeng, Ai-Hua Zhang, Xiao-Shuang Zheng, Peng Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 239686

Tóm tắt

Comorbidities, such as obesity, increase the risk of severe COVID-19. However, the mechanisms underlying severe illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out (