INTRODUCTION: Retinal vasculitis in the setting of positive CASE PRESENTATION: The clinical course of 3 patients with retinal vasculitis and mTB exposure were reviewed. Two patients were male, and 1 was female. Mean age at presentation was 56.8 years. Mean follow-up was 119.5 months. Mean presenting visual acuity was Snellen 20/25 in the right eye and 20/30 in the left eye. Mean visual acuity at final visit was 20/30 in both eyes. All 3 patients received antitubercular therapy (ATT). Two patients underwent retinal laser photocoagulation in one or both eyes. Two patients experienced multiple episodes of vitreous hemorrhage. One patient underwent pars plana vitrectomy for non-clearing vitreous hemorrhage in both eyes. CONCLUSION: The cases demonstrate the potential diagnostic and management variability created by the overlapping features of Eales disease and TRV. All 3 cases had some form of positive mTB testing (radiologic, immunologic, or both) and received different ATT regimens. Case 1 was labeled Eales disease, and cases 2 and 3 were labeled TRV. All 3 had favorable outcomes but only with control of the inflammation and neovascular complications. Recent consensus guidelines now provide guidance on ATT initiation in cases of TRV.