Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria-Associated ER Membrane.

• Tác giả: Shuangshuang Chen, Yong Fan, Shijun Hu, Wei Lei, Xuechun Li, Baoqiang Ni, Zhenya Shen, Min Song, Miao Yu, Jianyi Zhang, Manna Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 232.964 Burial
• Thông tin xuất bản: England : Cell proliferation , 2025
• Bộ sưu tập: NCBI
• ID: 240038

Tóm tắt

 m.3243A>
 G is the most common pathogenic mtDNA mutation. High energy-demanding organs, such as heart, are usually involved in mitochondria diseases. However, whether and how m.3243A>
 G affects cardiomyocytes remain unknown. We have established patient-specific iPSCs carrying m.3243A>
 G and induced cardiac differentiation. Cardiomyocytes with high m.3243A>
 G burden exhibited hypertrophic phenotype. This point mutation is localised in MT-TL1 encoding tRNA