A quantitative weight-of-evidence review of preclinical studies examining the potential developmental and reproductive toxicity of acetaminophen.

• Tác giả: Evren Atillasoy, Christopher Chu, Sadaff Ejaz, Bamidele O Jeminiwa, Daniel G Kougias, Michael Kovochich, Andrey Massarsky, Tammi H Schaeffer, Anthony R Scialli, Michael D Southall, Kenneth M Unice
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Critical reviews in toxicology , 2025
• Bộ sưu tập: NCBI
• ID: 241074

Tóm tắt

We previously developed a quantitative weight-of-evidence (QWoE) framework using prespecified scoring criteria for preclinical acetaminophen data to characterize potential developmental neurotoxicity outcomes with considerations for biological relevance of the response to adverse outcomes and the strength of methods and study design. The current analysis uses this framework to characterize potential developmental and reproductive toxicity (DART) outcomes following exposure to acetaminophen. Two-hundred forty-two QWoE entries were documented from