Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions

• Tác giả: Chiara Gabbiani
• Ngôn ngữ: eng
• ISBN-13: 978-8884539397
• ISBN-13: 978-8884539403
• ISBN-13: 978-8892737679
• Ký hiệu phân loại: 572 Biochemistry
• Thông tin xuất bản: Firenze : Firenze University Press, 2009
• Mô tả vật lý: 1 electronic resource (74 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 241158
• Chủ đề: 1. Biology, life sciences; 2. Physics

Tóm tắt

There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.