Nghiên cứu độc tính cấp và tác dụng bảo vệ gan của viên nén Bảo đường can PC trên mô hình gây viêm gan cấp bằng paracetamol thực nghiệm=Evaluating acute toxicity and liver protective effect on paracetamol - induced hepatotoxicity in mice model of Bao duong can PC tablet

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Hương Thu Bùi, Phương Thanh Mai, Thị Ngọc Ánh Nguyễn, Đức Hữu Trần, Thanh Tùng Trần, Ngô Bảo Long Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2024

Mô tả vật lý: tr.311-318

Bộ sưu tập: Metadata

ID: 242052

Thêm vào giỏ

Nghiên cứu độc tính cấp và đánh giá tác dụng bảo vệ tế bào gan của viên nén Bảo đường can PC trên chuột nhắt trắng chủng Swiss thông qua mô hình gây viêm gan cấp bằng Paracetamol. Đối tượng và phương pháp nghiên cứu: Nghiên cứu độc tính cấp của sản phẩm nghiên cứu được tiến hành trên chuột nhắt trắng theo đường uống và xác định LD50 theo phương pháp Litchfied-Wilcoxon
đánh giá tác dụng bảo vệ chức năng gan của Bảo đường can PC trên mô hình gây tổn thương gan cấp tính bằng Paracetamol trên chuột nhắt chủng Swiss. Kết quả: Chuột uống Bảo đường can PC ở mức liều cao nhất có thể không xuất hiện triệu chứng bất thường nào trong 72 giờ sau khi uống sản phẩm nghiên cứu. Kết quả nghiên cứu tác dụng bảo vệ gan của viên nén Bảo đường can PC ở 2 mức liều 1,44 viên/kg/ngày và 4,32 viên/kg/ngày trên mô hình thực nghiệm gây viêm gan cấp bằng Paracetamol cho thấy xu hướng cải thiện các chỉ số nghiên cứu so với lô mô hình. Kết luận: Chưa xác định được LD50 trên chuột nhắt trắng của Bảo đường can PC theo đường uống. Bảo đường can PC không gây biểu hiện độc tính cấp. Bảo đường can PC có tác dụng bảo vệ gan trên mô hình gây tổn thương gan thực nghiệm bằng Paracetamol.Research on acute toxicity and evaluate the liver protective effect of Bao duong can PC tablets on Swiss mice on the model of acute liver injury with Paracetamol. Research objects and methods: Acute toxicity of the research product was conducted on mice orally and determined according to the Litchfied-Wilcoxon method. Evaluation of the liver protective effect of Bao duong can PC tablets on the model of acute liver injury with Paracetamol in Swiss mice. Results: Monitoring showed that mice taking Bao duong can PC at different dosage levels did not show any unusual symptoms within 72 hours after taking the research product. Results of research: the liver protective effect of Bao duong can PC tablets at two dosage levels of 1.44 tablets/kg/day and 4.32 tablets/kg/day on an experimental model of acute hepatitis with Paracetamol shows that a trend of improvement in research indicators. Conclusion: LD50in Swiss mice of Bao duong can PC has not been determined orally. Bao duong can PC has a liver protective effect on the model of experimental liver damage with Paracetamol.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR