Kết quả xác định căn nguyên nhiễm trùng đường hô hấp dưới bằng film array ở bệnh nhân nội trú tại Bệnh viện Bệnh Nhiệt đới Trung ương 2020- 2022=Results of determining the cause of lower respiratory tract infections using film array in inpatients at the National Hospital for Tropical diseases from 2020 to 2022

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Tác giả: Nguyễn Minh Hoa Lê, Văn Duyệt Lê, Thị Thu Hà Nguyễn, Văn Thượng Nguyễn, Quyết Thắng Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2024

Mô tả vật lý: tr.204-209

Bộ sưu tập: Báo, Tạp chí

ID: 242161

Thêm vào giỏ

Characterization of the etiology of microorganisms causing lower respiratory tract diseases using automated multiplex PCR (Film Array) in patients with lower respiratory tract infections treated at the National Hospital for Tropical Diseases from 2020 to 2022. Methods: Retrospective study of 197 patients with lower respiratory tract infections who were prescribed Film Array and cultured at the National Hospital for Tropical Diseases from 2020 to 2022. Results: The Film Array positivity rate was 67%, and the culture rate was 33%. In which, the main typical bacteria are A. baumanii complex with the largest proportion of 22.95%, K. pneumonia 18.49%, S. aureus 7.53%, atypical bacteria L. pneumophila 0.34%, Coronavirus virus 3.55%, Human Rhinovirus 1.52%, In À uenza A 0.51%
9 typical virus-bacteria co-infected specimens. 290 antibiotic resistance gens were detected, CTX-M gen had the highest proportion of 25.9%, NDM, KPC, OXA-48 like gens had similar proportions, mecA/ and MREJ, VIM gens had the lowest proportion of 2.1%. Culture did not detect atypical bacteria, viruses and drug resistance gens. Conclusion: Film Array has a positive rate 2 times higher than culture in the study, detecting both atypical bacteria, viruses, virus-bacterial co-infection and drug resistance gens.Xác định đặc điểm căn nguyên vi sinh vật gây bệnh đường hô hấp dưới bằng kỹ thuật PCR đa mồi tự động (Film Array) và phương pháp nuôi cấy ở người bệnh nhiễm trùng đường hô hấp dưới điều trị tại Bệnh viện Bệnh nhiệt đới Trung ương giai đoạn 2020-2022. Phương pháp nghiên cứu: Nghiên cứu hồi cứu 197 bệnh nhân nhiễm trùng đường hô hấp dưới được chỉ định Film Array và nuôi cấy tại bệnh viện Bệnh nhiệt đới trung ương giai đoạn 2020- 2022. Kết quả: Tỷ lệ dương tính Film Array là 67%, nuôi cấy là 33%. Trong đó, chủ yếu là vi khuẩn điển hình A. baumanii complex chiếm tỉ lệ lớn nhất 22,95%, K. pneumonia 18.49%, S.aureus 7,53%, vi khuẩn không điển hình L. pneumophila 0.34%, virus Coronavirus 3.55%, Human Rhinovirus 1,52%, Influenza A 0,51%
9 bệnh phẩm đồng nhiễm virus- vi khuẩn điển hình. Phát hiện 290 lượt gen kháng kháng sinh, gen CTX-M chiếm tỷ lệ cao nhất 25,9%, gen NDM, KPC, OXA-48 like tỷ lệ tương đương nhau, gen mecA/ and MREJ, VIM có tỷ lệ thấp nhất 2,1%. Nuôi cấy không phát hiện được vi khuẩn không điển hình, virus và gen kháng thuốc. Kết luận: Film Array có tỷ lệ dương tính cao hơn 2 lần nuôi cấy trong nghiên cứu, phát hiện được cả vi khuẩn không điển hình, virus, đồng nhiễm virus- vi khuẩn và gen kháng thuốc.

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