Đánh giá hiệu lực phác đồ phối hợp metronidazole-ivermectine trong điều trị viêm da do demodex spp=Evaluate of combined metronidazole plus ivermectine efficacy in the treatment for human demodicosis

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Trung Dũng Đỗ, Hồng Quang Huỳnh, Đức Chính Nguyễn, Ngọc Vinh Nguyễn, Thị Thanh Quyên Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2024

Mô tả vật lý: tr.103-109

Bộ sưu tập: Metadata

ID: 242202

Thêm vào giỏ

Đánh giá hiệu lực phác đồ kết hợp metronidazole với ivermectine (MTZ+IVM) trong điều trị viêm da do Demodex spp. Phương pháp: Thử nghiệm lâm sàng không ngẫu nhiên, không đối chứng, đánh giá hiệu lực phác đồ MTZ+IVM trong điều trị viêm da do Demodex spp. Kết quả:Tổng số 80 bệnh nhân viêm da do Demodex spp. được đưa vào đánh giá hiệu lực thuốc kết hợp MTZ+IVM cho thấy giảm đáng kể các triệu chứng ngứa, châm chích, kiến bò và tổn thương đỏ da, dát đỏ, vảy da sau điều trị 1 và 2 tháng. Mật độ Demodex spp. giảm từ (8,8 ± 4,5) xuống còn (1,5 ± 1,1) và (0,6 ± 0,2) con/vi trường sau 1 và 2 tháng (p <
0,05). Mức độ đáp ứng tốt, trung bình và kém sau điều trị 1 và 2 tháng lần lượt 80,3% và 88,7%
13,2% và 5,6%
3,9% và 1,4%. Tỷ lệ không đáp ứng hoặc thất bại điều trị thời điểm sau 1 và 2 tháng lần lượt 2,6% và 4,3%. Một số tác dụng không mong muốn trong 10 ngày đầu gồm ngứa, rát tại thương tổn 2 ca (2,5%), mệt mỏi 6 ca (7,5%), hoa mắt, chóng mặt 2 ca (2,5%), đau bụng 3 ca (3,8%) và buồn nôn 3 ca (3,8%). Kết luận: Phác đồ phối hợp MTZ + IVM đã cải thiện có ý nghĩa viêm da Demodex spp. lần lượt từ 80,3% và 88,7% sau 1 tháng và 2 tháng.To evaluate of combined metronidazole plus ivermectine (MTZ+IVM) efficacy in treatment of human demodicosis. Methods: A non-randomized uncontrolled trial design for evaluate of combined MTZ+IVM regimen efficacy in treatment of human demodicosis. Results:The efficacy of combined MTZ+IVM regimen in the treatment for 80 enrolled demodicosis patients showed that significantly reduced of itching, stinging, crawling ants, and erythema/ red skin, and skin scales at points of before and after one and two months intervention
Demodex density reduced from 8.8±4.5 to 1.5±1.1 and 0.6±0.2/microscope field after 1 and 2 months, respectively. The proportion of high response, moderate response, and low response were 80.3% and 88.7%
13.2% and 5.6%
3.9% and 1.4% in one and two months post-treatment, respectively. Non-response or treatment failure at one and two months post-treatment were 2.6% and 4.3%.Some advert events in the first ten days since drugs taken included of itching, skin burning 2 (2.5%), fatigue 6 (7.5%), dizziness 2 (2.5%), abdomen pain 3 (3.8%), nausea 3 (3.8%). Conclusions:Combined MTZ+IVM regimen has high efficacy 80.3% and 88,7% at one and two months post-treatment, respectively.

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