Khảo sát mối liên quan giữa đa hình AGT M235t và tăng huyết áp tâm trương ở bệnh nhân đái tháo đường và bệnh thận đái tháo đường=Association between AGT M235t polymorphism and diastolic hypertension in patients with diabetic kidney disease

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Tác giả: Thị Thuý Hằng Nguyễn, Thọ Anh Nguyễn, Thị Thu Hương Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.55-61

Bộ sưu tập: Metadata

ID: 242614

Thêm vào giỏ

AGT gene encodes glycoprotein AGT, a precursor of the renin-angiotensin-aldosterone system (RAAS) that plays an important role in the biosynthesis of Ang II and aldosterone. Some mutations in the AGT gene are associated with hypertension, renal fibrosis, and progression of renal failure. Research objective: To investigate the association between the AGT M235T polymorphism and hypertension in patients with diabetes and diabetic kidney disease (DKD). Methods: A case-control study included 125 patients with DKD and 128 controls having type 2 diabetes without renal complications. The study was performed from March 2024 to July 2024 at Saint Paul General Hospital. Results: The patient group had an average age of 65.83 ± 7.78 years old, in which the youngest patient was 43 years old and the oldest patient was 80 years old. The average glomerular filtration rate of the patient group was 58.53 ± 20.65 ml/min/1.73m2. The rate of hypertension in the patient group was 100%, of which the rate of diastolic hypertension was 37.6%. Patients with the homozygous CC genotype of the AGT M235T polymorphism had a higher risk of diastolic hypertension than patients with the T allele genotype (OR: 8.06
95%CI: 1.31-49.46
p=0.024)Khảo sát mối liên quan giữa đa hình M235T gen AGT với tăng huyết áp ở người bệnh đái tháo đường và bệnh thận ĐTĐ. Đối tượng và phương pháp: Nghiên cứu bệnh chứng, bao gồm 125 người bị mắc bệnh thận đái tháo đường và 128 người đái tháo đường típ 2 không có biến chứng thận. Thời gian và địa điểm nghiên cứu từ 03/2024 đến 7/2024 tại Bệnh viện Đa khoa Xanh Pôn. Kết quả: Nhóm bệnh thận đái tháo đường có độ tuổi trung bình là 65,83 ± 7,78 tuổi, trong đó bệnh nhân có độ tuổi thấp nhất là 43 tuổi và cao nhất là 80 tuổi. Trung bình mức lọc cầu thận của nhóm bệnh là 58,53 ± 20,65 ml/phút/1,73m2. Tỉ lệ tăng huyết áp của nhóm bệnh là 100%, trong đó tỉ lệ tăng huyết áp tâm trương là 37,6%. Bệnh nhân mang kiểu gen đồng hợp tử CC gen AGT M235T có nguy cơ tăng huyết áp tâm trương cao hơn so với bệnh nhân mang kiểu gen alen T (OR: 8,06
95%CI: 1,31-49,46
p= 0,024).

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