Kháng thể kháng HLA sau ghép ở người bệnh giảm chức năng thận trong 6 tháng đầu sau ghép=Anti – HLA antibodies after transplantation in patients with renal dysfunction in the first 6 months after transplantation

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Văn Mạnh Bùi, Việt Thắng Lê, Thị Thu Hà Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.30-35

Bộ sưu tập: Metadata

ID: 242618

Thêm vào giỏ

Khảo sát kháng thể kháng HLA (PRA) sau ghép và tìm hiểu mối liên quan với một số yếu tố ở người bệnh có biến đổi chức năng thận theo dõi trong 6 tháng đầu sau ghép thận. Đối tượng và phương pháp: Tiến cứu, mô tả cắt ngang, theo dõi dọc sau ghép thận. Kết quả: Tỷ lệ BN có PRA dương tính sau ghép là 78,4% (chủ yếu là lớp II với 72,6%). Tỷ lệ bệnh nhân có PRA dương tính sau ghép cao hơn so với trước ghép (p <
0,05). Nguy cơ xuất hiện PRA (+) ở nhóm không hòa hợp HLA ≥ 3/6 cao hơn nhóm không hòa hợp HLA <
3/6 là 6,8 lần (p <
0,05). Kết luận: Sau ghép, PRA (+) với tỷ lệ cao chủ yếu là lớp II. Tỷ lệ PRA (+) sau ghép cao hơn so với trước ghép. Mức độ không hòa hợp HLA liên quan tới sự xuất hiện PRA (+).Survey of anti-HLA antibodies (PRA - Panel Reactive Antibodies) after transplantation and study of the relationship with some factors in patients with reduced kidney function in the first 6 months after transplantation. Patients and methods: Prospective, crosssectional, follow-up after transplantation. Results: The rate of patients with positive PRA after transplantation was 78.4% (mainly class II with 72.6%). The ratio of patients with positive PRA after transplantation was higher than before transplantation (p <
0.05). The risk of PRA (+) in the HLA incompatible group ≥ 3/6 was 6.8 times higher than in the HLA incompatible group <
3/6 (p <
0.05). Conclusion: After transplantation, PRA (+) with high rate is mainly class II. The ratio of PRA (+) after transplantation is higher than before transplantation. The level of HLA incompatibility is related to the appearance of PRA (+).

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR