Background: Surgical site infection is considered a very common hospital infection today, leading to severe complications, prolonged hospital stays, increased treatment costs, and even death. Gastrointestinal surgical procedures often carry a high risk of surgical site infections. Prophylactic antibiotics have been used for a long time to reduce the rate of surgical site infections at Hai Phong International Hospital, but there have not been any specific reports related to the use of antibiotics in surgical patients at the hospital. On that basis, recognizing the urgency of evaluating the situation of using prophylactic antibiotics in surgery at the hospital's surgery department, this study was conducted to describe the current status of prophylactic antibiotic use in gastrointestinal surgery patients at Hai Phong International hospital 2023. Method: Cross-sectional descriptive study through the retrospective review of medical records of surgery patients in the gastrointestinal department at Hai Phong International Hospital, Vietnam from January 1st to December 31st, 2023. Results: The median age of patient in this study was 51. The most common surgical sites were the anus and appendix, with rates of 55,6% and 22,64%, respectively. The predominant type of surgery was clean-contaminated, accounting for 63.81%. The most used antibiotics were Metronidazole (66.75%), Ampicillin/sulbactam (56.46%), Cefotaxime (23.21%), and Cefazolin (10.53%). The proportions of patients receiving appropriate prophylactic antibiotics with timing of drug administration, antibiotic selected, and doses were 98.56%, 63.87% and 60.77%, respectively. The overall appropriate prophylactic antibiotic was 3.35%. Conclusion: The overall appropriateness of prophylactic antibiotic use is relatively low (3,35%), the main reason is the inappropriate duration of administration (96,65%). In addition, the inappropriate selection and use of antibiotics contributed to the inappropriate antibiotic. Therefore, it is essential to develop guidelines for prophylactic antibiotic use to improve treatment outcomes.Background: Surgical site infection is considered a very common hospital infection today, leading to severe complications, prolonged hospital stays, increased treatment costs, and even death. Gastrointestinal surgical procedures often carry a high risk of surgical site infections. Prophylactic antibiotics have been used for a long time to reduce the rate of surgical site infections at Hai Phong International Hospital, but there have not been any specific reports related to the use of antibiotics in surgical patients at the hospital. On that basis, recognizing the urgency of evaluating the situation of using prophylactic antibiotics in surgery at the hospital's surgery department, this study was conducted to describe the current status of prophylactic antibiotic use in gastrointestinal surgery patients at Hai Phong International hospital 2023. Method: Cross-sectional descriptive study through the retrospective review of medical records of surgery patients in the gastrointestinal department at Hai Phong International Hospital, Vietnam from January 1st to December 31st, 2023. Results: The median age of patient in this study was 51. The most common surgical sites were the anus and appendix, with rates of 55,6% and 22,64%, respectively. The predominant type of surgery was clean-contaminated, accounting for 63.81%. The most used antibiotics were Metronidazole (66.75%), Ampicillin/sulbactam (56.46%), Cefotaxime (23.21%), and Cefazolin (10.53%). The proportions of patients receiving appropriate prophylactic antibiotics with timing of drug administration, antibiotic selected, and doses were 98.56%, 63.87% and 60.77%, respectively. The overall appropriate prophylactic antibiotic was 3.35%. Conclusion: The overall appropriateness of prophylactic antibiotic use is relatively low (3,35%), the main reason is the inappropriate duration of administration (96,65%). In addition, the inappropriate selection and use of antibiotics contributed to the inappropriate antibiotic. Therefore, it is essential to develop guidelines for prophylactic antibiotic use to improve treatment outcomes.