Catheter Ablation Improves Ventilatory Efficiency in Atrial Fibrillation-Mediated Cardiomyopathy.

• Tác giả: Hakam Abbass, Nikhil Ahluwalia, Ashley Ashdown, David Bruce, Anthony Chow, Mehul Dhinoja, Fabrizio Focacci, Shohreh Honarbakhsh, Ross J Hunter, Guy Lloyd, Steffen Petersen, Richard J Schilling
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of cardiovascular electrophysiology , 2025
• Bộ sưu tập: NCBI
• ID: 242725

Tóm tắt

 BACKGROUND: Exercise Oscillatory Ventilation (EOV) and a steep ventilatory efficiency (VE/VCO2) slope are features of ventilatory inefficiency on cardiopulmonary exercise testing (CPET), both associated with poor prognosis in patients with heart failure (HF). The prevalence in patients with co-existent atrial fibrillation (AF) and the impact of catheter ablation (CA) is unknown. OBJECTIVES: To characterize ventilatory inefficiency in patients with persistent AF and Left Ventricular Systolic Dysfunction (LVSD) and assess the impact of CA. METHODS: Patients with persistent AF and Left Ventricular Ejection Fraction (LVEF) <
  50% undergoing first-time CA were prospectively enrolled. Echocardiography and CPET were performed at baseline and 6 months post-CA. EOV was defined using the Kremser-Corrà criteria, and VE/VCO2 slope gradient >
  30 was considered abnormal. RESULTS: A total of 53 participants were enrolled (mean LVEF of 34 ± 9%). A total of 10 (19.2%) exhibited EOV at baseline. These patients had larger indexed left atrial (41.6 ± 13.1 mL/m CONCLUSIONS: Ventilatory inefficiency is common in patients with AF and LVSD. CA improves both EOV and VE/VCO2 in AF-induced cardiomyopathy. Improvement in P