So sánh liệu quả liệu pháp phối hợp chất ức chế kênh đồng vận chuyển natri-glucose 2 và liệu pháp truyền thống trong điều trị đái tháo đường típ 2 mắc kèm suy tim tại Bệnh viện Đa khoa Quốc tế Hải Phòng=Comparision of the effectiveness of combined therapy sodium-glucose transporter 2 inhibitors versus traditional therapy in treatment of type 2 diabetes with heart failure in Hai Phong International General Hospital

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Tác giả: Thị Thu Phương Nguyễn, Thị Ngân Trần, Vân Anh Trần, Mai Anh Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học Sức khỏe, 2024

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Bộ sưu tập: Metadata

ID: 242747

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To compare the effectiveness of a combination therapy involving sodium-glucose co-transporter 2 (SGLT2i) inhibitors with traditional therapy in treating type 2 diabetes mellitus (T2DM) accompanied by heart failure, the research team conducted a retrospective study on 106 medical records, including 53 patients treated with traditional therapy and 53 patients treated with combination therapy. This study aimed to achieve two objectives: comparing the effectiveness of the SGLT2i combination therapy against the traditional therapy in treating T2DM with concurrent heart failure. After 3 months of treatment, both patient groups showed a reduction in HbA1C, with the traditional therapy group showing a decrease of 0.71% and the SGLT2i group showing a decrease of 0.72%. This difference was not statistically significant (p >
0.05). Similarly, the percentage of patients achieving the target HbA1C and fasting plasma glucose levels increased in both groups, with the SGLT2i group experiencing a greater increase, although the difference was not statistically significant (p >
0.05). The mean BNP levels also decreased in both groups, with a greater reduction in the SGLT2i group (12.54 pg/mL) compared to the traditional group (7.07 pg/mL)
however, this difference was not statistically significant (p >
0.05). Notably, the weight reduction in the SGLT2i group (1.25 kg) was significantly more than in the traditional therapy group (0.44 kg), and this difference was statistically significant (p <
0.05). Overall, the results indicate that the SGLT2i combination therapy offers some benefits over traditional therapy, but the differences in treatment effectiveness between the two groups were not statistically significant for most parameters.Với mục đích so sánh hiệu quả của liệu pháp điều trị phối hợp chất ức chế kênh đồng vận chuyển natri-glucose 2 (SGLT2i) so với liệu pháp truyền thống trong điều trị ĐTĐ típ 2 mắc kèm suy tim,nhóm nghiên cứu tiền hành hồi cứu trên 106 hồ sơ bệnh án bao gồm 53 bệnh nhân được điều trị liệu pháp truyền thống và 53 bệnh nhân điều trị liệu pháp phối hợp nhằm thực hiện hai mục tiêu so sánh hiệu quả của liệu pháp điều trị phối hợp chất ức chế kênh đồng vận chuyển natri-glucose 2 so với liệu pháp truyền thống trong điều trị ĐTĐ típ 2 mắc kèm suy tim. Sau 3 tháng điều trị, cả hai nhóm bệnh nhân đều cho thấy sự giảm HbA1C, trong đó nhóm liệu pháp truyền thống giảm 0,71% và nhóm SGLT2i giảm 0,72%. Sự khác biệt này không có ý nghĩa thống kê (p >
0,05). Tương tự, tỷ lệ bệnh nhân đạt mục tiêu HbA1C và Glucose huyết tương lúc đói đều tăng ở cả hai nhóm, với nhóm SGLT2i tăng nhiều hơn, nhưng không có sự khác biệt đáng kể về mặt thống kê (p >
0,05). BNP trung bình cũng giảm ở cả hai nhóm, nhóm SGLT2i giảm nhiều hơn (12,54 pg/mL) so với nhóm truyền thống (7,07 pg/mL), tuy nhiên, sự khác biệt này không có ý nghĩa thống kê (p >
0,05). Điểm đáng chú ý là giảm cân ở nhóm SGLT2i (1,25 kg) nhiều hơn so với nhóm truyền thống (0,44 kg), và sự khác biệt này có ý nghĩa thống kê (p <
0,05). Nhìn chung, kết quả cho thấy liệu pháp phối hợp SGLT2i mang lại một số lợi ích hơn so với liệu pháp truyền thống, nhưng sự khác biệt về hiệu quả điều trị giữa hai nhóm không có ý nghĩa thống kê đối với hầu hết các chỉ số.

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