Suy giảm chức năng phổi ở bệnh nhân sau điều trị lao phổi khỏi bệnh tại Thành phố Hồ Chí Minh=Lung function impairment among patients with cured pulmonary tuberculosis in Ho Chi Minh City

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hồng Đức Nguyễn, Văn Thọ Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.344-351

Bộ sưu tập: Metadata

ID: 243570

Thêm vào giỏ

Khảo sát tỉ lệ và mức độ suy giảm chức năng phổi và mô tả các triệu chứng hô hấp dai dẳng của bệnh phổi sau lao (BPSL) trong số bệnh nhân vừa điều trị khỏi bệnh lao phổi. Phương pháp: Nghiên cứu cắt ngang, thu nhận tất cả bệnh nhân được chẩn đoán và điều trị lao phổi, có kết quả chức năng phổi sau điều trị khỏi lao phổi tại một phòng khám chuyên khoa lao và bệnh phổi tại Thành phố Hồ Chí Minh. Chức năng phổi được đánh giá dựa trên hô hấp ký và/hoặc phế thân ký gần nhất của bệnh nhân. Triệu chứng hô hấp dai dẳng được ghi nhận dựa vào hồi cứu hồ sơ bệnh án. Phân tích số liệu bằng phần mềm SPSS. Kết quả: Trong thời gian từ 1/1/2020 đến 1/4/2024 có tổng cộng 325 bênh nhân được ghi nhận chẩn đoán lao phổi khỏi bệnh. Trong số đó có 223 bệnh nhân thỏa tiêu chuẩn chọn mẫu, gồm 83 nữ và 140 nam. Chức năng phổi gồm 136 hô hấp ký và 87 phế thân ký. Rối loạn thông khí được ghi nhận ở 79,9% trường hợp, gồm: 100 bệnh nhân (44,8%) có rối loạn thông khí tắc nghẽn, 58 bệnh nhân (26,0%) có rối loạn thông khí hạn chế và 18 bệnh nhân (8,1%) có rối loạn thông khí hỗn hợp. Hút thuốc lá là yếu tố tăng nặng cho tình trạng tắc nghẽn. Các triệu chứng hô hấp dai dẳng thường gặp nhất theo thứ tự giảm dần bao gồm: ho, khạc, và khó thở với tần suất 68,2%, 55,6%, và 40,8%. Kết luận: Một tỉ lệ tương đối cao bệnh nhân đã điều trị khỏi lao phổi vẫn còn triệu chứng hô hấp dai dẳng và suy giảm chức năng phổi. Cần có thêm nghiên cứu với cỡ mẫu lớn hơn, bao gồm cả chức năng phổi, hình ảnh học lồng ngực, chất lượng cuộc sống, các dấu ấn sinh học, để có bức tranh rõ ràng hơn về BPSL tại Việt Nam.To evaluate the prevalence and severity of lung function impairment and to describe persistent respiratory symptoms of posttuberculosis lung disease among patients with bacteriologically cured pulmonary tuberculosis. Methods: In this cross-sectional study, we recruited all patients who had been diagnosed and treated for pulmonary tuberculosis, had lung function tests after pulmonary tuberculosis treatment at a tuberculosis and lung disease clinic in Ho Chi Minh City. Lung function was assessed by using the most recent spirometry and/or plethysmography results. Persistent respiratory symptoms were retrospectively recorded from medical records. Data were analyzed by using SPSS software. Results: Between January 1, 2020, and April 1, 2024, a total of 325 patients with pulmonary tuberculosis had been diagnosed and cured bacteriologically. Among them, 223 patients (83 women and 140 men) met inclusion criteria. Lung function tests included 136 spirometries and 87 plethysmographies. Lung function impairment was observed in 79.9% of cases, including 100 patients (44.8%) with obstructive ventilatory defect, 58 patients (26.0%) with restrictive ventilatory defect, and 18 patients (8.1%) with mixed ventilatory defect. Cigarette smoking exacerbated obstructive ventilatory defect. The most common persistent respiratory symptoms in the declining frequency included cough (68.2%), sputum production (55.6%), and dyspnea (40.8%). Conclusion: A relatively high proportion of patients with cured pulmonary tuberculosis still have persistent respiratory symptoms and lung function impairment. Further research with larger sample size, incorporating lung function, thoracic imaging, quality of life assessments, and biomarkers, is necessary to comprehensively understand post-tuberculosis lung disease in Vietnam.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR