Hiệu quả của súc miệng povidone iodine 1% kết hợp mật ong trong điều trị giảm đau vùng miệng do xạ trị ung thư đầu cổ=The efficacy of povidone iodine 1% mouthwash combined with honey in the treatment of radiation - induced oral pain in patients with head and neck cancer

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Tác giả: Hữu Trình Lê, Thị Kim Chi Nguyễn, Đắc Tuyến Võ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.132-139

Bộ sưu tập: Metadata

ID: 243667

Thêm vào giỏ

Đau vùng miệng là một trong những biến chứng thường gặp nhất trong xạ trị ung thư đầu cổ làm bệnh nhân bị khó nhai, nuốt dẫn đến tình trạng dinh dưỡng kém. Mục tiêu: Xác định hiệu quả của súc miệng Povidone Iodine 1% (PVP-I 1%) kết hợp mật ong trong điều trị giảm đau vùng miệng do xạ trị ung thư đầu cổ. Đối tượng và phương pháp: Nghiên cứu thử nghiệm lâm sàng ngẫu nhiên có nhóm chứng ở bệnh nhân ung thư đầu cổ đến khám và điều trị tại Khoa Xạ trị đầu cổ, tai mũi họng, hàm mặt tại Bệnh viện Ung Bướu Thành phố Hồ Chí Minh từ tháng 10/2022 - 06/2023, đánh giá và so sánh mức độ đau tại các thời điểm 1, 2, 3, 4, 5 tuần từ khi bắt đầu xạ trị, thời điểm kết thúc xạ trị và sau xạ trị 1 tháng. Kết quả: Trong quá trình xạ trị, cả 2 nhóm đều có hiệu quả giảm đau vùng miệng tại thời điểm tuần 2, 3, 4, 5 tính từ khi bắt đầu xạ trị. Hiệu quả giảm đau của nhóm PVP-I 1% kết hợp mật ong rõ rệt hơn nhóm PVP-I 1% (p <
0,05). Tại thời điểm kết thúc xạ trị (T6), cả 2 nhóm đều có hiệu quả giảm đau vùng miệng nhưng hiệu quả giảm đau nhóm PVP-I 1% kết hợp mật ong hơn rõ rệt so với nhóm PVP-I 1% (p <
0,05). Tại thời điểm tái khám 1 tháng sau xạ trị (T7), cả 2 nhóm đều có hiệu quả giảm đau tương đương nhau (p >
0,05). Kết luận: Hiệu quả giảm đau vùng miệng trong quá trình xạ trị (tính từ tuần thứ 2 từ thời điểm bắt đầu xạ trị) và tại thời điểm kết thúc xạ trị của nhóm PVP-I 1% kết hợp mật ong rõ rệt hơn nhóm sử dụng PVP-I 1% đơn thuần (p <
0,05).Oral pain is one of the most common complications in radiation therapy for head and neck cancer, making it difficult for patients to chew and swallow, leading to poor nutritional status. Objective: The efficacy of Povidone Iodine 1% (PVP-I 1%) combined with honey in the treatment of oral pain caused by radiation therapy of head and neck cancer was examined. Methods: Randomized controlled clinical trial study was conducted on head and neck cancer patients from Ho Chi Minh City Oncology Hospital from 10/2022 - 06/2023. Pain intensity was measured and compared at times 1, 2, 3, 4, 5 weeks from the beginning of radiation therapy, the time of completion of radiation therapy and 1 month after radiation therapy. Results: During radiation therapy, both groups were effective at reducing oral pain in weeks 2, 3, 4, and 5. The analgesic effect of the 1% PVP-I group combined with honey was more pronounced than that of the 1% PVP-I group (p <
0.05). At the end of radiotherapy (T6), both groups were effective at relieving oral pain, but the pain relief of the PVP-I 1% combined with honey was significantly higher than that of the PVP-I 1% (p <
0.05). 1 month after radiation therapy (T7), both groups had similar analgesic efficacy (p >
0.05). Conclusion: The analgesic effect of the oral pain during radiotherapy (from week 2) and at the end of radiation of the PVP-I group 1% combined with honey was more pronounced than that of the PVP-I group alone (p <
0.05).

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