Đặc điểm nồng độ insulin máu và tình trạng kháng insulin trên bệnh nhân thừa cân, béo phì bằng mô hình HOMA2-IR tại Bệnh viện Chợ Rẫy=Assessment of blood insulin levels and insulin resistance in overweight and obese individuals using the HOMA2-IR model at Cho Ray Hospital

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Tác giả: Hà Khánh Linh Dương, Tấn Sơn Lê, Chí Thanh Nguyễn, Thành Vinh Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.266-272

Bộ sưu tập: Báo, Tạp chí

ID: 243744

Thêm vào giỏ

To determine the blood insulin levels and insulin resistance in overweight and obese individuals. Research patients and methods: A cross-sectional descriptive study was conducted on 80 overweight and obese individuals at Cho Ray Hospital outpatient clinic. The blood insulin levels were measured using chemiluminescence immunoassay, and insulin resistance was assessed using the HOMA2-IR index. Results: Fasting blood insulin levels in the study population were 10.25 (6.82 – 14.40) μU/mL
in the insulin-resistant group, the level was 15.10 (12.28 - 18.58) μU/mL, significantly higher than the non-insulin-resistant group (6.90 (5.18 – 8.62) μU/mL, p<
0.01). The prevalence of insulin resistance in overweight and obese individuals according to the HOMA2-IR model was 47.5%. There was a significant difference in the prevalence of insulin resistance between males (32.5%) and females (62.5%) (p<
0.01). Conclusion: Fasting blood insulin levels in overweight and obese individuals were 10.25 (6.82 – 14.40) μU/mL. The prevalence of insulin resistance in overweight and obese individuals according to the HOMA2-IR model was 47.5%.Xác định nồng độ insulin và tỷ lệ kháng insulin trên bệnh nhân thừa cân, béo phì. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang có phân tích trên 80 đối tượng thừa cân, béo phì tại Khoa Khám Bệnh Bệnh Viện Chợ Rẫy. Nồng độ insulin máu được đo bằng phương pháp miễn dịch hóa phát quang, đề kháng insulin được xác định bằng chỉ số HOMA2-IR. Kết quả: Nồng độ insulin máu lúc đói ở đối tượng nghiên cứu là 10,25 (6,82 – 14,40) μU/mL
ở nhóm có đề kháng insulin là 15,10 (12,28 - 18,58) μU/mL cao hơn so với nhóm không đề kháng insulin là 6,90 (5,18 – 8,62) μU/mL (p<
0,01). Tỷ lệ đề kháng insulin trên bệnh nhân thừa cân, béo phì theo mô hình HOMA2-IR là 47,5%. Có sự khác biệt giữa tỷ lệ đề kháng insulin ở nam là 32,5% và nữ là 62,5% (p<
0,01). Kết luận: Nồng độ insulin máu lúc đói ở bệnh nhân thừa cân, béo phì là 10,25 (6,82 – 14,40) μU/mL. Tỷ lệ đề kháng insulin trên bệnh nhân thừa cân, béo phì theo mô hình HOMA2-IR là 47,5%

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