Khảo sát tỷ lệ nhiễm HPV theo độ tuổi dựa trên xét nghiệm HPVmRNA E6/E7 ở bệnh nhân khám tại Bệnh viện Phụ Sản Quốc Tế Sài Gòn=Study on age-specific prevalence of human papilloma virus based on expression of HPVmRNA E6/E7 in patients at Saigon International Obst-Gynec Hospital

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Tác giả: Thị Bích Thuận Huỳnh, Hoàng Anh Phạm, Trung Hà Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.244-251

Bộ sưu tập: Metadata

ID: 243750

Thêm vào giỏ

Determine HPV prevalence using HPV mRNA E6/E7 testing. Study of trend in HPV infection rate among women age in patients at Sai Gon international OBST-GYNEC hospital. Methods: Cross-sectional study described 7.154 cases of women (17-87 age) who visited Sai Gon international OBST-GYNEC hospital from January, 2023 to May, 2024. HPV mRNA E6/E7 test is an in vitro nucleic acid amplification test for the qualitative detection of E6/E7 viral messenger RNA (mRNA) from 14 high-risk types of HPV. Results: The prevalence of HPV infection was 13,3%
HPV type 16 prevalence was 11,1%, HPV type 18/45 were 8,0%, coinfection with HPV type 16, 18/45 were 0,8% and other highrisk types of HPV were 80,1%. The highest prevalence of HPV infection was observed in younger aged 17 to 29 years was 22,0%, the lower second group in aged 30 to 39 years was 16,2%, the third in aged 40 to 49 was 11,4% and finally lowest group in aged 50 to 87 years was 8,9%. There is a statistically significant relationship between HPV prevalence and age (p <
0,001). Conclusions: The prevalence of HPV infection using HPV mRNA E6/E7 test in patients at Sai Gon international OBST-GYNEC hospital was 13,3%. HPV infection prevalence decreased with increasing age from a peak prevalence in younger women is similar to the result of other studies.Xác định tỷ lệ nhiễm HPV dựa trên xét nghiệm HPV mRNA E6/E7. Đặc điểm tỷ lệ nhiễm HPV theo độ tuổi trên bệnh phân khám phụ khoa tại Bệnh viện phụ sản quốc tế Sài Gòn. Đối tượng - phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả 7.154 phụ nữ có độ tuổi từ 17 đến 87 tuổi khám tại Bệnh viện phụ sản quốc tế Sài Gòn từ tháng 01/2023 đến tháng 05/2024. Phương pháp xét nghiệm HPV mRNA phát hiện mục tiêu là các mRNA từ biểu hiện vùng gen sinh ung E6/E7 của 14 type HPV nguy cơ cao. Kết quả: Tỷ lệ nhiễm HPV là 13,3%
trong đó nhiễm HPV type 16 chiếm 11,1%, HPV type 18/45 chiếm 8,0%, đồng nhiễm HPV nhóm type 16, 18/45 chiếm 0,8% và HPV 11 type nguy cơ cao khác là 80,1%. Đỉnh cao tỷ lệ nhiễm HPV ở nhóm phụ nữ trẻ 17-29 tuổi (22,0%), đứng thứ 2 là nhóm 30-39 tuổi (16,2%), kế tiếp là nhóm 40- 49 tuổi (11,4%) và cuối cùng là nhóm 50-87 tuổi (8,9%). Có mối tương quan giữa độ tuổi và tình trạng nhiễm HPV (p <
0,001). Kết luận: Tần suất nhiễm HPV dựa trên xét nghiệm HPV mRNA E6/E7 tại Bệnh viện phụ sản quốc tế Sài Gòn là 13,3%. Đỉnh cao tỷ lệ nhiễm HPV ở nhóm phụ nữ trẻ và suy giảm theo nhóm tuổi càng cao tương tự với kết quả của các nghiên cứu khác.

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