Khảo sát nguy cơ tiền sản giật quý 1 dựa trên mô hình yếu tố nguy cơ mẹ và mô hình phối hợp FMF tại hệ thống y tế Medlatec=Risk of preeclampsia in first-trimester screening using the maternal factors and the FMF algorithm in Medlatec healthcare system

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Tác giả: Văn Trân Phạm, Văn Chiều Trần, Thùy Anh Triệu, Thị Quế Trịnh, Anh Tuấn Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.225-231

Bộ sưu tập: Metadata

ID: 243754

Thêm vào giỏ

Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Early screening and preventive treatment help minimize the risk of preeclampsia during pregnancy. Objective: to determine the risk of preeclampsia based on the maternal risk factor model and the FMF model
the relationship between the risk of preeclampsia and clinical and laboratory factors. Subjects: Pregnant women with gestational age from 11 weeks 01 day to 13 weeks 06 days who was examinated and screened for pre-eclampsia in the first trimester at MEDLATEC Healthcare system from May 2023 to the end of April 2024. Methods: retrospective cross-sectional study. Statistical analysis using SPSS 22.0 software. Results: 9,86% of participants have high risk for first trimester preeclampsia screening when using the FMF algorithm, significantly higher than using the maternal risk factor model (1,68%). The concentration of serum maternal PAPP-A and PlGF in high risk group (3,42 ± 2,40 and 34,78 ± 19,28) are significantly lower than the low risk group (4,87 ± 3,06 and 57,40 ± 26,07
p<
0,001). Maternal age >
35, assisted reproduction, nulliparity, maternal serum PAPP-A concentration <
0,4 MoM, maternal serum PlGF concentration <
100 pg/mL are the risk factor of high risk for first trimester preeclampsia screening. Conclusion: First trimester screening for pre-eclampsia using FMF algorithm should be applied to every pregnant women for risk assessment and preventive treatment if needed.Tiền sản giật là một trong những nguyên nhân hàng đầu gây bệnh tật và tử vong cho mẹ và thai nhi. Việc sàng lọc phát hiện và điều trị dự phòng sớm giúp giảm thiểu nguy cơ khởi phát tiền sản giật trong suốt thai kì. Mục tiêu: Xác định nguy cơ tiền sản giật dựa trên mô hình yếu tố nguy cơ mẹ và mô hình phối hợp FMF
mối liên quan giữa nguy cơ tiền sản giật với một số yếu tố lâm sàng và cận lâm sàng. Đối tượng: Thai phụ có tuổi thai từ 11 tuần 01 ngày đến 13 tuần 06 ngày tới khám và sàng lọc tiền sản giật quý 1 tại Hệ thống Y tế MEDLATEC từ tháng 5 năm 2023 đến hết tháng 04 năm 2024. Phương pháp: Nghiên cứu mô tả cắt ngang, hồi cứu. Phân tích số liệu thống kê dựa trên phần mềm SPSS 22.0. Kết quả: Có 9,86% thai phụ có kết quả nguy cơ cao với tiền sản giật khi sử dụng mô hình sàng lọc FMF, cao hơn đáng kể so với mô hình sử dụng yếu tố nguy cơ mẹ theo hướng dẫn Bộ Y tế (1,68%). Nồng độ huyết thanh các dấu ấn PAPP-A và PlGF của các thai phụ thuộc nhóm nguy cơ cao (3,42 ± 2,40 và 34,78 ± 19,28) thấp hơn rõ rệt so với nhóm nguy cơ thấp (4,87 ± 3,06 và 57,40 ± 26,07
p<
0,001). Tuổi mẹ >
35 tuổi, hỗ trợ sinh sản, mang thai lần đầu, nồng độ PAPP-A <
0,4 MoM, nồng độ PlGF <
100 pg/mL và MAP >
88,5 mmHg là các đối tượng có nguy cơ với tiền sản giật cao hơn. Kết luận: Sàng lọc tiền sản giật quý 1 bằng mô hình FMF nên được áp dụng cho tất cả các thai phụ nhằm tăng khả năng phát hiện nguy cơ cao với tiền sản giật để có biện pháp dự phòng hiệu quả.

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