Xây dựng khoảng tham chiếu xét nghiệm TSH ở phụ nữ mang thai ba tháng đầu trên máy DxI 800 tại Bệnh viện Đa khoa Quốc Tế Vinmec Times city=Establishment of reference interval for TSH serum in the first trimester of pregnancy on the DxI 800 machine at Vinmec Times City International Hospital

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Tác giả: Hồng Quân Dương, Gia Bình Nguyễn, Thị Lương Nguyễn, Từ Trung Nguyễn, Thị Hằng Giang Phan, Quỳnh Trang Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.211-218

Bộ sưu tập: Metadata

ID: 243758

Thêm vào giỏ

To determine a reference interval for TSH in the first trimester of pregnancy and apply the TSH reference interval in diagnosing thyroid disorders during early pregnancy at Vinmec Times City International Hospital. Subjects and methods: A crosssectional study of 1625 pregnant women in the first trimester (782 pregnant women and 843 pregnant women were enrolled in the first and the second objective, respectively) at Vinmec Times City Hospital from January 2022 to June 2024. Non-parametric analysis (2,5-97,5th percentile) was performed to determine the reference interval. Levels of TSH and FT4 were determined by the DxI 800 machine (Backman Coulter label, America). Results: The TSH reference interval was 0,14-2,27 mIU/L. The prevalence of thyroid disorders assessed according to the specific TSH reference interval was 28,9%, larger when evaluated according to ATA 2017 (20,2%) with p<
0,001 Conclusion: The TSH reference interval in pregnant women in the first trimester at Vinmec Times City Hospital was 0,14-2,27 mIU/L. The prevalence of thyroid disorders assessed according to the specific TSH was 28,9%. The population- and first-trimester-specific TSH reference interval should be used to assess thyroid function accurately.Xây dựng khoảng tham chiếu xét nghiệm TSH ở phụ nữ mang thai 3 tháng đầu và ứng dụng khoảng tham chiếu TSH này trong chẩn đoán bệnh lý tuyến giáp ở phụ nữ mang thai quý đầu tại bệnh viện đa khoa quốc tế Vinmec Timescity. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 1625 phụ nữ mang thai quý I (với 782 thai phụ ở mục tiêu 1 và 843 thai phụ ở mục tiêu 2) đến khám tại bệnh viện Vinmec Times City từ tháng 1 năm 2022 đến tháng 6 năm 2024. Nồng độ TSH và FT4 được định lượng bằng máy xét nghiệm miễn dịch DxI 800. Phân tích phi tham số (bách phân vị thứ 2,5- 97,5) được thực hiện để xác định khoảng tham chiếu. Tỷ lệ rối loạn chức năng tuyến giáp (RLCNTG) dựa vào khoảng tham chiếu xây dựng ở mục tiêu đầu và khoảng tham chiếu của ATA 2017. Kết quả: Khoảng tham chiếu TSH ở quý đầu thai kì là 0,14-2,27 mIU/L. Tỷ lệ thai phụ có RLCNTG đánh giá theo khoảng tham chiếu TSH xây dựng ở mục tiêu đầu là 28,9%, lớn hơn khi đánh giá theo tiêu chuẩn ATA 2017 (20,2%) có ý nghĩa thống kê với p<
0,001. Kết luận: Khoảng tham chiếu TSH ở phụ nữ mang thai (PNMT) 3 tháng đầu tại bệnh viện đa khoa quốc tế Vinmec Timescity là 0,14-2,27 mIU/L. Tỷ lệ thai phụ có RLCNTG đánh giá theo khoảng tham chiếu này là 28,9%. Khuyến nghị sử dụng khoảng tham chiếu nồng độ TSH xây dựng riêng cho từng vùng địa lý, phòng xét nghiệm khi tầm soát bệnh lý tuyến giáp ở phụ nữ mang thai 3 tháng đầu.

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