Liên quan giữa kiểm soát glucose máu và rối loạn lipid máu trên bệnh nhân đái tháo đường typ 2 tại Bệnh viện Thanh Nhàn=Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients at Thanh Nhan Hospital

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Tác giả: Minh Hiền Nguyễn, Tiến Long Nguyễn, Thị Chi Mai Trần, Việt Hải Long Trương, Thị Châm Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.131-137

Bộ sưu tập: Metadata

ID: 243782

Thêm vào giỏ

HbA1c is a marker used to monitor blood glucose control in patients with type 2 diabetes. Previous studies have shown a correlation between blood glucose control and blood lipid levels in patients with type 2 diabetes. Objective: To determine the relationship between HbA1c levels and blood lipid concentrations in type 2 diabetes patients at Thanh Nhan Hospital. Subjects and Methods: A cross-sectional descriptive study on 200 type 2 diabetes patients attending outpatient care at the Department of Internal Medicine, Thanh Nhan Hospital from March 2023 to May 2023. Results: In the HbA1c >
7.0% group, the proportion of patients with dyslipidemia (TC >
5.2
TG >
1.7
HDL-C <
1.0
Non HDL-C >
3.37 mmol/L) was higher than in the HbA1c <
7.0% group, with a statistically significant difference of p <
0.05. Similarly, in the HbA1c >
7.0% group, the proportion of patients with abnormal lipid ratios (LDL-C/HDL-C >
3.0, TC/HDL-C >
4.5, TG/HDL-C >
0.87) was higher than in the HbA1c <
7.0% group, with a statistically significant difference of p <
0.05. There was a significant positive correlation between HbA1c and total cholesterol (TC) (r= 0.420), triglycerides (r= 0.226), LDL-C (r= 0.166), non HDL-C (r= 0.466), LDL-C/HDL-C ratio (r= 0.379), TC/HDL-C ratio (r= 0.485), TG/HDL-C ratio (r= 0.219), p<
0.05. There was a significant negative correlation between HbA1c and HDL-C (r= -0.306), p<
0.05. Conclusion: The significant correlation between HbA1c and blood lipid parameters suggests the importance of blood glucose control as well as the management of dyslipidemia to further reduce the risk of cardiovascular disease in type 2 diabetes patients. The study results provide additional evidence suggesting that HbA1c, besides its function in monitoring blood glucose, may also be used as an important marker to predict dyslipidemia in patients with type 2 diabetes.HbA1c là một xét nghiệm được sử dụng để theo dõi kiểm soát glucose máu trên bệnh nhân đái tháo đường (ĐTĐ). Các nghiên cứu trước đây cho thấy mối liên quan giữa việc kiểm soát glucose máu và các chỉ số lipid máu ở bệnh nhân ĐTĐ typ 2. Mục tiêu nghiên cứu: Xác định mối liên quan giữa chỉ số HbA1c và nồng độ lipid máu ở bệnh nhân ĐTĐ typ 2 tại Bệnh viện Thanh Nhàn. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang hồi cứu trên 200 bệnh nhân đái tháo đường týp 2 đến khám, điều trị ngoại trú tại Khoa khám bệnh, Bệnh viện Thanh Nhàn từ tháng 3 năm 2023 đến tháng 5 năm 2023. Kết quả: Ở nhóm HbA1c >
7,0%, tỷ lệ bệnh nhân có rối loạn lipid máu (các chỉ số TC >
5,2
TG >
1,7
HDL-C <
1,0
Non HDL-C >
3,37 mmol/L) cao hơn ở nhóm HbA1c <
7%, sự khác biệt có ý nghĩa thống kê với p <
0,05. Tương tự, ở nhóm HbA1c >
7,0%, tỷ lệ bệnh nhân có các tỷ số lipid bất thường (LDLC/ HDL-C >
3,0, TC/HDL-C >
4,5 , TG/HDL-C >
0,87) cao hơn ở nhóm HbA1c <
7,0%, sự khác biệt có ý nghĩa thống kê với p <
0,05. Có mối tương quan thuận có ý nghĩa thống kê giữa HbA1c với cholesterol toàn phần (TC) (r= 0,420), triglycerid (r= 0,226), LDL-C (r= 0,166), non HDL-C (r= 0.466), các tỷ số LDL-C/HDL-C (r= 0,379), TC/HDL-C (r= 0,485), TG/HDL-C (r= 0,219), p<
0,05. Có mối tương quan nghịch giữa HbA1c với HDL-C (r= -0.306), p<
0,05. Kết luận: Mối tương quan có ý nghĩa giữa HbA1c và các thông số lipid máu gợi ý tầm quan trọng của việc kiểm soát glucose máu cũng như quản lý rối loạn lipid máu, nhằm giảm hơn nữa nguy cơ bệnh tim mạch ở bệnh nhân ĐTĐ typ 2.

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