Nghiên cứu nồng độ TAS, MDA huyết tương và một số yếu tố nguy cơ ở người tăng huyết áp=Study on TAS, MDA plasma concentrations, and some risk factors in people with hypertension

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Tác giả: Thu Nga Hoàng, Thị Bích Ngọc Nguyễn, Thị Diệp Anh Nguyễn, Thị Đức Hạnh Phạm, Thiện Ngọc Phạm, Thanh Dương Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.96-102

Bộ sưu tập: Metadata

ID: 243797

Thêm vào giỏ

Khảo sát mối liên quan của một số yếu tố nguy cơ gây tăng huyết áp với nồng độ TAS (Total Antioxidant Status) và MDA (Malondialdehyde) huyết tương ở người tăng huyết áp (THA). Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang ở 67 người THA tuổi 40-69. Sử dụng bộ câu hỏi phỏng vấn và cân đo nhân trắc để thu thập các yếu tố nguy cơ: hoạt động thể lực, hút thuốc lá, sử dụng rượu bia, thừa cân béo phì, béo bụng. Nồng độ TAS huyết tương (HT) được đo trên máy AU480 của hãng Beckman coulter. Nồng độ MDA HT được đo trên máy UV-Vis của hãng Shimadzu. Kết quả: Nhóm người THA và hút thuốc lá, nồng độ TAS HT (1,42 ± 0,12 mmol/L) và nhóm THA có sử dụng rượu bia ở mức cao, nồng độ TAS HT (1,45 ± 0,12 mmol/L) đều thấp hơn tương ứng so với nồng độ TAS HT ở nhóm THA không hút thuốc lá (1,59 ± 0,28 mmol/L) và nhóm THA sử dụng rượu bia mức thấp (1,59 ±0,18 mmol/L) lần lượt với p<
0,01 và p<
0,05. Nồng độ MDA HT trung bình ở nhóm hút thuốc lá (2,47 ± 0,40 nmol/L) cao hơn so với nhóm không hút thuốc lá (2,21 ± 0,34 nmol/L) với p <
0,05. Kết luận: Ở những người THA, việc sử dụng thuốc lá và uống rượu bia ở mức nguy cơ cao làm tăng quá trình peroxy hóa lipid (MDA) và giảm nồng độ tổng các chất chống oxy hóa (TAS) trong huyết tương.Survey of the relationship between some risk factors for hypertension and plasma TAS (total antioxidant status) and MDA (malondialdehyde) concentrations in hypertensive people. Subjects and methods: A cross-sectional study conducted in Thai Nguyen City in 67 patients with hypertension aged 40-69. Interview questionnaires and anthropometric measurements were used to collect risk factors including physical activity, smoking, alcohol consumption, overweight/obesity, and abdominal obesity. Plasma TAS concentration was measured on a Beckman Coulter AU480 machine. Plasma MDA concentration was measured on a Shimadzu UV-Vis machine. The study was conducted from February to December 2023. Results: Among hypertensive patients, the mean TAS concentration in the smoking group (1.42 ± 0.12 mmol/L) and the high-risk alcohol consumption group (1.45 ± 0.12 mmol/L) were both lower than the non-smoking group (1.59 ± 0.28 mmol/L) and the low-risk alcohol consumption group (1.59 ±0.18 mmol/L) respectively, with p<
0.01 and p<
0.05
the mean MDA concentration in the smoking group (2.47 ± 0.40 nmol/L) was higher than in the nonsmoking group (2.21 ± 0.34 nmol/L) with p <
0.05. Conclusion: Among hypertensive patients, smoking and high-risk alcohol consumption increase lipid peroxidation (MDA) and reduce total antioxidant status (TAS) in the blood.

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