BACKGROUND: Research into brain mechanisms and their impact on quality of life has gained significant traction, emphasising stress management, cognitive enhancement, and emotional well-being as essential components. OBJECTIVE: This study explores the relationship between brain health and overall wellness, focusing on neurobiological mechanisms and evidence-based interventions that enhance stress resilience in neurodivergent populations. METHODS: A comprehensive review of neuroscience and psychological literature was conducted, including neuroimaging and behavioural studies to assess the effectiveness of various interventions. RESULTS: Findings indicate that targeted strategies - such as Acceptance and Commitment Therapy (ACT), cognitive training, and lifestyle modifications - significantly improve stress resilience, cognitive abilities, and emotional regulation. Key brain regions involved include the amygdala, prefrontal cortex, and hippocampus. CONCLUSIONS: Implementing evidence-based interventions fosters improved quality of life through enhanced brain wellness. Future research should focus on scalable approaches that are inclusive of diverse populations.