Hiệu quả của Perampanel trong điều trị động kinh kháng thuốc ở trẻ em tại Bệnh viện Đa khoa Tâm Anh Hà Nội: Nghiên cứu trên 39 trường hợp=Effectiveness of Perampanel in treatment of drug-resistant epilepsy in children at Tam Anh General Hospital, Hanoi: Study on 39 cases

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Tác giả: Thị Hậu Kiều, Thu Hà Nguyễn, Thu Thảo Nguyễn, Văn Liệu Nguyễn, Thị Hinh Vũ

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.73-78

Bộ sưu tập: Metadata

ID: 243914

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Perampanel is a new generation antiepileptic drug with a selective mechanism of action on AMPA receptors. Currently, data on the use of Perampanel in the treatment of epilepsy in children are still limited. We conducted this study to evaluate the effectiveness and side effects of Perampanel in the treatment of drug-resistant epilepsy in children. Methods: Observational, retrospective study conducted at Tam Anh General Hospital, Hanoi, on a group of drug-resistant epilepsy patients in children aged 18 years and younger treated with Perampanel and monitored at the Hospital. Tam Anh General Hospital from 2020 to 2024. The effectiveness and side effects after using Perampanel are recorded. Results: There were 39 patients (21 men, 18 women) with an average age of 14.18 ± 3.66 years, the youngest being 4 years old and the oldest being 18 years old. Regarding classification, 3 patients (accounting for 10.3%) were diagnosed with generalized epilepsy, 26 patients (66.7%) were diagnosed with partial epilepsy, and the remaining 10 patients (accounting for 25.6%) had unknown diagnostic classification. guess. The average number of antiepileptic drugs used before combining Perampanel was 3.08 ± 1.42 types. Overall response rate after combining Perampanel: 15.4% of patients had no attacks and 61.5% reduced the number of attacks. There were 9 patients (23.1%) whose clinical condition did not change after adding Perampanel. The majority of patients (84.6%) were started with a 2mg dose of Perampanel. There were 7 patients (17.9%) with side effects, of which the most common were fatigue (3 patients) and drowsiness (3 patients), but all were mild. Conclusion: Perampanel may help improve the effectiveness of epilepsy treatment in children. Common side effects are fatigue and drowsiness.Perampanel là một thuốc chống động kinh thế hệ mới với cơ chế tác động chọn lọc lên thụ thể AMPA. Hiện nay những dữ liệu về việc sử dụng Perampanel trong điều trị động kinh ở trẻ em vẫn còn hạn chế. Chúng tôi thực hiện nghiên cứu này nhằm đánh giá hiệu quả và tác dụng phụ của Perampanel trong điều trị động kinh kháng thuốc ở trẻ em. Phương pháp nghiên cứu: Nghiên cứu quan sát, hồi cứu thực hiện tại Bệnh viện Đa khoa Tâm Anh Hà Nội, trên nhóm bệnh nhân động kinh kháng thuốc ở trẻ em từ 18 tuổi trở xuống được điều trị với Perampanel và theo dõi tại Bệnh viện Đa khoa Tâm Anh từ năm 2020 đến năm 2024. Kết quả: Có tổng cộng 39 bệnh nhân (21 nam, 18 nữ) với tuổi trung bình là 14,18 ± 3,66, nhỏ nhất là 4 tuổi và lớn nhất là 18 tuổi. Về phân loại, 3 bệnh nhân (chiếm 10,3%) được chẩn đoán động kinh toàn thể, 26 bệnh nhân (66,7%) được chẩn đoán động kinh cục bộ, còn lại 10 bệnh nhân (chiếm 25,6%) không rõ phân loại chẩn đoán. Số loại thuốc kháng động kinh trung bình được sử dụng trước khi phối hợp Perampanel là 3,08 ± 1,42 loại. Tỷ lệ đáp ứng chung sau khi phối hợp Perampanel: 15,4% người bệnh không có cơn và 61,5% giảm số cơn. Có 9 bệnh nhân (23,1%) không thay đổi tình trạng lâm sàng sau khi dùng thêm Perampanel. Đa số bệnh nhân (84,6%) được khởi đầu với liều Perampanel 2mg. Có 7 bệnh nhân (17,9%) có tác dụng phụ, trong đó thường gặp nhất là mệt mỏi (3 bệnh nhân) và buồn ngủ (3 bệnh nhân), tuy nhiên đều ở mức độ nhẹ. Kết luận: Perampanel có thể giúp cải thiện hiệu quả điều trị động kinh ở trẻ em. Các tác dụng phụ thường gặp là mệt mỏi, buồn ngủ.

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