Đánh giá tác dụng dự phòng tụt huyết áp của Ondansetron liều 8mg trong gây tê tủy sống cho phẫu thuật lấy thai tại Bệnh viện Đa khoa Tâm Anh=Evaluating the prophylactic effect of ondansetron 8 mg on hypotension during spinal anesthesia in cesarean sections at Tam Anh Hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Minh Hiếu Khổng, Quốc Kính Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.59-65

Bộ sưu tập: Báo, Tạp chí

ID: 243918

Thêm vào giỏ

Gây tê tủy sống ở sản phụ mổ lấy thai có nguy cơ gây ra tụt huyết áp và nhịp tim chậm, gây ảnh hưởng tới tính mạng sản phụ. Hiệu quả của ondansetron đối với dự phòng hạ huyết áp đối với sản phụ chưa được nghiên cứu rõ. Mục tiêu: Nghiên cứu này nhằm mục tiêu đánh giá hiệu quả dự phòng tụt huyết áp của ondansetron liều 8 mg trong gây tê tuỷ sống cho phẫu thuật lấy thai Phương pháp nghiên cứu: Nghiên cứu thử nghiệm lâm sàng, ngẫu nhiên có đối chứng, tiến cứu trên 87 sản phụ mổ lấy thai có thể trạng và tiền sử bình thường. Trong đó 44 bệnh nhân nhóm Ondansetron sử dụng ondansetron 8mg tiêm tĩnh mạch trước khi gây tê tủy sống 1 phút. Nhóm chứng là 43 bệnh nhân sử dụng giả dược là nước muối sinh lý tiêm tĩnh mạch trước khi gây tê tủy sống 1 phút. Đánh giá hiệu quả can thiệp dựa vào huyết áp tâm thu, nhịp tim và các tác dụng phụ sau phẫu thuật. Kết quả: Tại thời điểm ban đầu huyết áp tâm thu ở cả nhóm Ondansetron và nhóm đối chứng lần lượt là 120,5 ± 6,5 và 120,8 ± 14,3. Sau can thiệp, nhóm Ondasetron có huyết áp ổn định với trung bình 111,7 ± 18,9, huyết áp tối đa giảm đáng kể ở nhóm đối chứng với trung bình 79,9 ± 10,3 (p <
0,001). Nhịp tim cũng tăng cao ở nhóm đối chứng với trung bình 108,6 nhịp/phút cao hơn đáng kể so với nhóm sử dụng Ondasetron với trung bình là 83,6 nhịp/phút (p <
0,001). Kết luận: Ondasetron đã chứng minh được hiệu quả trong việc dự phòng tụt huyết áp ở sản phụ mổ lấy thai.Women undergoing cesarean sections with spinal anesthesia are at risk of developing hypotension and bradycardia, which can endanger maternal health. The prophylactic efficacy of ondansetron for hypotension in this demographic remains inadequately explored. Objective: This study assesses the effectiveness of an 8 mg dose of ondansetron in preventing hypotension associated with spinal anesthesia in cesarean deliveries. Methods: This prospective, randomized controlled trial involved 87 women scheduled for cesarean sections under spinal anesthesia, who were otherwise healthy and without significant medical histories. Participants were divided into two groups: the intervention group (n=44), which received 8 mg of intravenous ondansetron 5 minutes prior to anesthesia, and the control group (n=43), which received an intravenous saline placebo under the same conditions. The primary outcomes measured were systolic blood pressure, heart rate, and the incidence of postoperative side effects. Results: Initial systolic blood pressures were comparable between the intervention (120.5 ± 6.5 mmHg) and control groups (120.8 ± 14.3 mmHg). Post-intervention, the ondansetron group maintained more stable blood pressures (111.7 ± 18.9 mmHg) compared to the control group, which exhibited a significant decrease (79.9 ± 10.3 mmHg) (p <
0,001). The control group also experienced a higher increase in heart rate (108.6 beats/minute) than the ondansetron group (83.6 beats/minute) (p <
0,001). Conclusion: Ondansetron administration prior to spinal anesthesia in cesarean sections effectively mitigates the risk of hypotension, suggesting its utility as a prophylactic intervention.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR