Vai trò của thuốc Perampanel trong điều trị bệnh nhân động kinh kháng thuốc tại Bệnh viện Đa khoa Tâm Anh=The role of Perampanel in treatment of drug resistant epilepsy patients at Tam Anh General Hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Hậu Kiều, Thu Hà Nguyễn, Thu Thảo Nguyễn, Văn Liệu Nguyễn, Thị Hinh Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.53-58

Bộ sưu tập: Metadata

ID: 243923

Thêm vào giỏ

Đánh giá vai trò của Perampanel trong điều trị động kinh kháng thuốc tại Bệnh viện Đa khoa Tâm Anh Hà Nội. Phương pháp nghiên cứu: Nghiên cứu quan sát, hồi cứu thực hiện trên 215 bệnh nhân động kinh kháng thuốc được điều trị với Perampanel tại Bệnh viện Đa khoa Tâm Anh từ năm 2020 đến năm 2024. Kết quả: Nghiên cứu được thực hiện trên 215 bệnh nhân (54,9% nam, 45,1% nữ) với tuổi trung bình là 27,73 ± 11,60, độ tuổi nhỏ nhất là 4 tuổi và lớn nhất là 65 tuổi. Về phân loại, 24 bệnh nhân (11,2%) được chẩn đoán động kinh toàn thể, 140 bệnh nhân (65,1%) được chẩn đoán động kinh cục bộ, còn lại 23,7% không phân loại. Tỷ lệ đáp ứng chung sau khi phối hợp Perampanel đạt 77,2%, trong đó 19.1% người bệnh không còn cơn và 58,1 % giảm số cơn. Có 47 bệnh nhân (21,9%) đánh giá tình trạng lâm sàng không thay đổi và 2 bệnh nhân (0,9%) có cơn nặng hơn sau khi dùng thêm Perampanel. Có 155 bệnh nhân (72,1%) được khởi đầu với liều điều trị Perampanel là 2mg và 55 bệnh nhân khởi đầu điều trị với liều 4mg (25,6%) trong khi có 5 trường hợp không rõ liều khởi đầu do chuyển đến từ cơ sở điều trị khác. Có 22 bệnh nhân (9,3%) bệnh nhân ghi nhận có tác dụng phụ, trong đó thường gặp nhất là mệt mỏi (3,7%) và buồn ngủ (4,2%), tuy nhiên đa số đều ở mức độ nhẹ. Ngoài ra có thể gặp tác dụng phụ khác như ăn kém, rối loạn trí nhớ, chóng mặt, đau đầu. Có 1 bệnh nhân gặp tình trạng dị ứng thuốc với biểu hiện mẩn ngứa ngoài da và phải ngưng thuốc. Kết luận: Perampanel có thể giúp cải thiện hiệu quả điều trị động kinh kháng thuốc khi dùng phối hợp với các thuốc chống động kinh khác. Một số tác dụng phụ thường gặp phải như mệt mỏi, buồn ngủ.Evaluate the role of Perampanel in the treatment of drug resistant epilepsy patients at Tam Anh General Hospital, Hanoi. Method: Observational, retrospective study conducted on 215 patients who met the diagnostic criteria for drug-resistant epilepsy and were treated with Perampanel at Tam Anh General Hospital from 2020 to 2024. Results: 215 patients (54.9% male, 45.1% female) with an average age of 27.73 ± 11.60 years, ranging from 4 to 65 years old, were included in the study. Regarding classification, 24 patients (11.2%) were diagnosed with generalized epilepsy, 140 patients (65.1%) with focal epilepsy, and the remaining 23.7% were unclassified. The overall response rate after the addition of Perampanel was 77.2%, with 19.1% of patients becoming seizure-free and 58.1% experiencing a reduction in seizure frequency. There were 47 patients (21.9%) whose clinical status remained unchanged and 2 patients (0.9%) who experienced worsened seizures after adding Perampanel. A total of 155 patients (72.1%) started treatment with an initial Perampanel dose of 2mg, and 55 patients (25.6%) began with a 4mg dose, while 5 cases had unknown initial doses due to being referred from other treatment facilities. 22 patients (9.3%) reported side effects, the most common being fatigue (3.7%) and drowsiness (4.2%), most of which were mild. Other side effects included poor appetite, memory disturbances, dizziness, and headaches. One patient experienced a drug allergy manifesting as skin rash and had to discontinue the medication. Conclude: Perampanel can help improve the effectiveness of treatment for drug-resistant epilepsy when used in combination with other antiepileptic drugs. Some common side effects include fatigue and somnolence.

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