Nghiên cứu hoạt tính kháng viêm của chiết xuất jatropha podagrica hook thu hái tại Đồng Nai=Anti-inflammation activity of jatropha podagrica hook extracts collecting in Đong Nai

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Tác giả: Lời Huỳnh, Thị Hồng Khuyên Phạm, Đạo Cường Tô, Mạnh Hùng Trần, Phú Chí Hiếu Trương, Thị Giang Trương

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Công nghệ Đồng Nai, 2024

Mô tả vật lý: tr.141-152

Bộ sưu tập: Metadata

ID: 244029

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Cây dầu lai có củ (DLCC), Jatropha podagrica Hook. thuộc họ Euphorbiaceae thường được sử dụng trong y học dân gian để điều trị táo bón, nhiễm trùng da, vàng da và sốt. Loại cây này có nhiều tác dụng dược lý khác nhau, bao gồm kháng khuẩn, chống ung thư, chống oxy hóa, ức chế sự phát triển của côn trùng, ức chế thần kinh cơ và hạ huyết áp. Tuy nhiên, hoạt tính chống viêm của nó vẫn chưa được khám phá. Trong nghiên cứu này, chiết xuất từ lá, thân và rễ của cây DLCC đã được nghiên cứu trên mô hình tế bào RAW264.7 được kích thích gây viêm bởi lipopolysaccharide (LPS). Kết quả cho thấy phân đoạn etyl axetat (EtOAc) từ rễ cây DLCC ức chế mạnh quá trình sinh tổng hợp oxit nitric (NO), với giá trị IC50 là 112,6 ± 8,5 µg/mL. Ngoài ra, chiết xuất EtOAc từ rễ cây DLCC làm giảm sự biểu hiện protein cyclooxygenase-2 (COX-2) và nitric oxit synthase cảm ứng (iNOS) bằng phương pháp Western Blot. Những kết quả này cho thấy các chất chiết xuất và các phân đoạn từ DLCC có đặc tính chống viêm đầy hứa hẹn, và có thể là nguồn tài nguyên quý giá để phát triển thành thuốc kháng viêm trong tương lai.Jatropha podagrica Hook. belongs to the Euphorbiaceae family, and has been traditionally used in folk medicine to alleviate constipation, skin infections, jaundice, and fever. This plant exhibits various pharmacological effects, including antibacterial, anticancer, antioxidant, insect growth inhibition, neuromuscular inhibition, and hypotensive properties. However, its anti-inflammatory activity remains unexplored. In this study, extracts from the leaves, stems, and roots of Jatropha podagrica were investigated using the RAW264.7 cells model, which was stimulated with lipopolysaccharide (LPS) to induce inflammation. The findings revealed that the ethyl acetate (EtOAc) fractional from Jatropha podagrica roots exhibited potent inhibition of nitric oxide (NO) biosynthesis, with an IC50 value of 112.6 ± 8.5 µg/mL. Additionally, the EtOAc extract from Jatropha podagrica roots reduced the protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in protein expression models. These results suggest that extracts and fractions derived from Jatropha podagrica possess promising anti-inflammatory properties, highlighting their potential as valuable resources for the development of future anti-inflammatory drugs.

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